Here is My Question:
I've had 2 half infusions of Ocrevus for PPMS. Out of 7 symptoms all are gone except drop foot. I'm hoping to see better mobility with full infusion in August. I've only partial foot drop so if lesions are shrinking foot drop should continue to improve. What are your thoughts please.
If you are asking if I think it is likely your symptoms will continue to improve with further Ocrevus treatments, I have no data to answer this question. Almost all of our studies in MS are designed to determine if the treatment delays or prevents disease progression, not to determine if the therapy is associated with either transient or continued improvement in function. Many studies will report post hoc analyses that suggest improvement, but these are often difficult to interpret particularly in relapsing MS patients, who can and often do improve spontaneously even when receiving placebo treatment.
I am not aware of any post hoc analyses from the Ocrevus primary progressive phase III study that demonstrated any continued improvement in function. The relapsing remitting Ocrevus studies reported a marginal benefit on disability improvement compared to the control group that received Rebif. Specifically, 20.7 % of Ocrevus RRMS patients experienced disability improvement compared to 15.6 % of Rebif patients (33 % difference). This is not a result that we can necessarily apply to primary progressive patients.
I am happy to hear of your positive results with Ocrevus and hope you continue to see improvement in your symptoms and function. Keep working hard and don't discard the importance of your hard work and positive attitude on achieving your goals.
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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