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There's a report out that Ocrevus canceled out chicken pox antibodies in someone with RRMS. How does that affect someone with PPMS who would like to get the shingles vaccine Shingrix?
B-cell biologics can lower antibody production levels and can hamper the humoral immune response to vaccination. When b-cells are transiently absent (depleted) after an infusion, vaccines are less effective and should be planned in a timeframe that takes this into account. The exact number of b-cells needed to mount a robust antibody response is of research interest right now.
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist at Kaiser Permanente
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