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I've been injecting Copaxone 20 mg and then it's generic form for three months now (newly diagnosed RR). I have also become incredibly sick with a virus one month (lasted five days), and bacterial infections (upper respiratory, eyes; lasting 5-7 days) the subsequent two months. I've also had a week of relapses all three months. My understanding was Copaxone/Glatopa was not an immune suppressant but was instead supposed to increase the amount of healthy white blood cells and their action in my immune system, reduce relapse rates and slow lesion/disease progression. Instead, I feel as if everything's becoming worse in my body. What is happening? How can I be this sick with a virus or bacterial infection monthly, continue relapsing (though I'm relapsing a bit less) and have any sort of life? Is this common for users of this drug? I'm beside myself. Answer: There are many potential explanations for the recurrent infection but without knowing the details of your case it is hard for me to comment. What I can tell you is the following: 1. Copaxone or Glatopa does not suppress your immune system and I doubt it is responsible for the prolonged infection 2. Steroids can suppress your immune system, so if you received steroids in the past 3 months this may be your explanation 3. All disease modifying therapies like Copaxone take time to start working. It is not unusual for people to relapse in the first few months on treatment. It is the relapses beyond the first three months of treatment that create greater concern that the drug will not be effective if continued Good luck Revere (Rip) Kinkel MD Director of the Multiple Sclerosis Program Professor of Clinical Neurosciences University of California San Diego
Jennifer Narraway
8/22/2015 11:49:19 am
Dr. Kinkel, Thank you very much for taking the time to answer my question(s). I haven't ever had steroids, and never became sick monthly with viruses/bacterial infections until after I was diagnosed and started injections. Interestingly, there are only two correlations I can discern regarding the monthly illnesses. One: they always occur during the week of my period. Second: it was suggested by a doctor that my extremely high stress level and subsequent increased clinical depression/anxiety (previously diagnosed in my early twenties, with a continuing fluctuation of both conditions since that time--I am now 42) might be impacting my immune system negatively. Is it possible I'm becoming ill because of a heightened inflammatory response driven by hormonal changes during my period and my current mental health status is increasing the negative impact on my immune system? Do Copaxone and/or Glatopa have any impact on my hormones? Thank you, again.
Dr Kinkel
8/26/2015 12:51:17 am
You are very perceptive. Chronic stress suppresses adaptive immune responses and increases the risk of all types of infections. Menstruation also increases your risk of urinary tract infections. It can take years of chronic stress before we notice an increase in infections. It is not clear to me how either Copaxone or Glatopa could further increase your risk of infections. Comments are closed.
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