Tysabri is a humanized monoclonal antibody that binds to an adhesion molecule on immune cells and prevents the cells from gaining entry into the brain.
Anti-Lingo-1 is a humanized monoclonal antibody developed by Biogen Idec that binds to Lingo-1, a molecule expressed on the surface of oligodendrocyte precursor cells (cells that make myelin) that prevents oligodendrocytes from remyelinating axons (it is negative regulator of myelination). In animal models Anti-Lingo-1 promotes remyelination and is being tested in phase II studies of MS patients.
Although both drugs are monoclonal antibodies they have totally different effects on the body and nervous system.
-Rip Kinkel, MD
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