Here is My Question:
What is PML?
PML stands for Progressive Multifocal Leukoencephalopathy. This is viral infection of the brain caused by a mutated, "neurotropic" version of a common virus called the JC virus or Human Polyomavirus 2. Many if not most people are exposed to this virus in life, and it tends to remain dormant in your body without causing any initial or subsequent symptoms or disease. Under certain conditions of immunosuppression, a mutated version of the virus can proliferate and infect the brain causing PML. This is very difficult to treat unless the condition is detected prior to symptom onset (usually an MRI scan) and only if it is possible to reverse the immunosuppression rapidly. PML is most commonly observed in people with HIV and immunosuppression before they start highly active retroviral therapy. The emergence of PML in some individuals treated with Natalizumab (Tysabri), a therapy not considered a broad immunosuppressant, taught us a lot about PML prevention. Because of this knowledge there has been a dramatic reduction in cases of PML in the United States since 2012.
Revere P (Rip) Kinkel, MDProfessor of Neurosciences
Director of the Multiple Sclerosis Program
University of California San Diego
#PML #JCvirus #MS #multiplesclerosis
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