Here is My Question:
After much consideration, I have made the decision to switch from Ocrevus to Tysabri. The options I am weighing are to either go to Kesimpta or Tysabri. Since Kesimpta is similar to Ocrevus I have decided to go with Tysabri due to the decline (clinically) that I was seeing with Ocrevus.
Anyway, I have seen a lot of postings from people going from Ocrevus to Tysabri but not many the other way around. Is this a change that you see often?
Also, in reading about Tysabri, I am wary of a couple of things:
1)PML- Although my JCV level is relatively low, 0.34, I would be lying if this does not worry me.
2)I know that due to the PML risk, Tysabri is usually not a drug that one is on for many years; I am concerned about "AFTER TYSABRI," as I have read, even on this site, "there is an increased risk of relapsing, usually within 6 months of stopping Tysabri."
My MS has declined clinically in the last few years; going from walking normally to using a cane sometimes due to leg weakness, and also much more spasms and spasticity, but my MRIs have remained stable.
I guess my main concern is since I have been so “stable,” with minimal decline, is going on Tysabri “worth the risk” of both PML as well as relapsing after stopping.
Please let me know your thoughts on this.
Those are a lot of good questions. First let me eliminate some misinformation included in your question about the use of Tysabri
Revere (Rip) Kinkel MD
Director of the Multiple Sclerosis Program
Professor of Clinical Neurosciences
University of California San Diego
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