I am starting Ocrevus next month and my doc wants me off Tecfidera for one month prior. Why do I need to be off for so long prior since Tecfidera has such a short half life?
One reason to stop Tecfidera for a month or longer before starting Ocrevus is to make sure your blood lymphocyte count returns to the normal range. This helps minimize the risk of further immunosuppression.
If your blood counts and lab work is normal, there I see little reason to wait a month.
Many doctors have different levels of comfort when switching from one DMT to another and prefer to play things safe. It’s important for both the patient and the doctor to feel comfortable with the treatment decision; waiting one month will probably not adversely affect your treatment.
Revere (Rip) Kinkel MD
Professor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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