Question About Taking Estriol And A Disease Modifying Therapy for MS

Here is My Question:
I have been taking various DMTs since I was diagnosed with MS 17 years ago.
Currently I am taking a compound of estriol and Copaxone due to the promising results posted so far by Dr. Voskhul. Currently there are studies of estriol with other DMT in 4 universities. In your opinion, due to the simplicity of taking an oral pill (Gilenya) along with Estriol, would this be sufficient? Dr. Voskhl chose Copaxone because the results of this drug would take a long time, so the study of estriol could be examined exclusively. Thank you!

Answer:
I am not aware of any ongoing or published studies of estriol in combination with any DMT other than Copaxone. This is confirmed by a review of registered studies at the clinicaltrials.gov website.
Rhonda Voskhul’s preliminary phase II study showed potential benefits of estriol in combination with Copaxone on the reduction of relapse rates in the first year of treatment; this benefit disappeared over the second year of treatment. There are many potential reasons for this loss off efficacy over time and it is too early to advocate for using this or any other DMT in combination with estriol in clinical practice. Phase III studies will resolve this issue and, more importantly, phase III studies will help us understand if estriol has any effect on physical or cognitive disability progression or surrogate markers of disability progression.

Rip Kinkel

PLEASE NOTE:  The information/opinions on this site should be used as an information resource only.  This information does not create any patient-HCP relationship, and should not be used as a substitute for professional diagnosis and treatment.  Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition.