My doctor changed my Tysabri to 6 weekly infusions and I don't feel the same

Here is My Question:
For the past 7 years I've been on Tysabri every 4 weeks but my neurologist decided to change it to 6 weekly infusions much to my disgust 😥 and I don't feel the same. I'm more tired and I'm weaker and my head is constantly sore. HELP

Answer:
There are several good reasons to switch an individual on Tysabri to every 6 week infusions after a year or more of stability on every 4 week infusions. These reasons include the following:

1. No prior history of chemotherapy or immunosuppression with a JCV index > 0.9 (some argue even those with lower index values are at too high a risk of PML), especially if older age (> 55) and lightweight (< 60 Kg) 
2. A prior history of chemotherapy or immunosuppression and any level positive JCV index

If you are in a risk group for PML (see above), you understand these risks and are willing to take these risks, I suggest you discuss your concerns directly with your neurologist and ask to be switched back to every 4 week infusions. Most of us have not experienced any significant problems switching people from every 4 week to every 6 week infusions. That being said, this is still anecdotal information. There is a controlled clinical trial underway to determine if there is any difference in efficacy between every 4 week and every 6 week infusions. Only this study will give us the level 1 evidence still needed to answer your question.

Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego