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Hi, I recently tested positive for JCV, after nearly 40 months of taking Tysabri. I have been offered the chance to take Rituxan off label for my MS. My question is this: Would I be at increased risk for PML on Rituxan having taken Tysabri? I've noticed in my reading that PML with Rituxan is often affected by prior therapies that affect immune function....How long after my last Tysabri infusion would I wait to start the Rituxan? Would the protocol of 1,000mg every six months be advisable? Or is there another dosing schedule that might be more effective? Thank you in advance for answering my question. There seems to be so little information out about Tysabri patients using Rituxan.... Answer: You are correct; there is little written about Rituximab in general since it is not approved by the FDA for an indication to treat MS. All very good questions. Please see some of my prior postings which consider this subject in more detail. (Just go to the search box at the top right of the page and type in PML). Let’s break your question down:
If you start the Rituximab immediately, you will need to have your MS specialist continue to monitor you for the development of PML. The information/opinions on this site should be used as an information resource only. This information does not create any patient-HCP relationship, and should not be used as a substitute for professional diagnosis and treatment. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition.
Alex
6/9/2014 01:29:54 am
Were there rebounds observed after switching from Tysabri to Rituximab? Thanks! Comments are closed.
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PLEASE NOTE: This information/opinions on this site should be used as an information source only. This information does not create any patient-HCP relationship, and should not be used as a substitute for professional diagnosis and treatment. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition.
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