Is there a connection between multiple sclerosis and low grade fevers?

Question:
​My question is if there is a connection between MS and running low grade fever (~99.5+)? I am about 4.5 months off Tysabri, and scheduled to start Ocrevus at the end of December. For the last two weeks I have been running a low grade fever, on and off, though more on. At the same time, I have been more fatigued. After a few days, I was checked for flu, along with a few negative blood tests. No indication of infection, but if it persists, I'll get further checked out. While the greater fatigue is likely due to the rise in body temperature, I wonder if the fever itself could be associated with the MS, perhaps indicating disease activity and inflammation? A bit of internet research showed this question on MS boards, along with stabs at an answer by fellow board mates, however, I could not find the question addressed by any experts or health professionals.

Answer:
Low grade or any grade fever would not be a manifestation of MS. If anything patients with longstanding MS tend to run lower temperatures.

Revere (Rip) Kinkel MD
Professor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego