Is it possible to have lesions lower in the spine that would not have been caught on the brain and neck MRI that could be diagnosed as MS even with a normal spinal tap?
Here is My Question:
I have 5 members in my family including my sibling that have been diagnosed with MS, I have several symptoms and they have gotten worse over the past 5 years such as, painful, severe, frequent muscle spasms (no less than 10 per hour that jump all over my body, similar to what you would see with an ALS patient), electric or crawling feeling through my body, memory loss/confusion, numbness and tingling in all extremities that come and go, loss of balance, double vision, troubles swallowing, small nerve fiber neuropathy, difficulty speaking and remembering words. My EMG studies have come back abnormal and 2 1/2 years ago my MRI of neck and brain as well as spinal tap came back normal. Is it possible to have lesions lower in the spine that would not have been caught on the brain and neck MRI that could be diagnosed as MS even with a normal spinal tap?
People with MS do not experience small fiber neuropathies or any form of sensory neuropathy. Remember, MS is a disease of the central nervous system and neuropathies, by definition, are diseases of the peripheral nervous system. It is certainly possible to have "lesions" in the thoracic spinal cord and not see lesions in the brain or cervical spinal cord in people with MS but it would be rare after 5 years of symptoms
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
PLEASE NOTE: This information/opinions on this site should be used as an information source only. This information does not create any patient-HCP relationship, and should not be used as a substitute for professional diagnosis and treatment. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition.