Here is My Question:
I have had 2 rounds of Lemtrada.
I responded well after the first round. I have regressed 1 yr after round 2.
Loss of strength, foot drop, spasticity.
No new lesions shown in recent MRI but limp and discomfort are obvious.
We are discussing either a 3rd round of Lemtrada or a different DMD.
I have been on Avonex and Tecfidera previously.
We had thought Lemtrada would slow my progression but it has not.
Contemplating stem cell.
There are many reasons for a lack of response to immunotherapy in MS, but a very common reason is lack of anticipated response. By this, we mean that the individual on therapy is either in a progressive phase of the disease or over the age of 55, an age generally associated with a diminished response to currently available DMTs.
HSCT is most effective and currently justified in ambulatory, relapsing MS patients under the age of 45 with evidence of activity (relapse or MRI) in the prior 2 years despite highly active DMTs.
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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