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Here is My Question:
Ive come off Tysabri due to the JC virus. How long until my immune system is back to normal?
The question to ask isn't so much when the immune system is back to normal (because the medication doesn't alter the intrinsic function of the lymphocytes of the immune system, but more a question of when immunosurveillance is reconstituted). Trafficking of these immune cells into the central nervous system slowly returns, and we discovered with the RESTORE study (monitoring of disease activity after discontinuing tysabri) that rebound inflammatory activity is at the highest risk between 3 and 6 months after discontinuing tysabri. Another question is, 'what is my risk for PML after stopping tysabri?'. The answer to that question is approximately 6 months.
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist at Kaiser Permanente
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