Here is My Question:
Does a person's height have anything to do with the effects of medications such as Baclofen? I am very short and wonder if the medicine lasts longer for me and I should take it less frequently.
The size of a person, which is partially governed by height, can affect the volume of distribution and half-life of many medications. Doctors and pharmacists should be well trained in these particulars. This is particularly important for medications with a small "therapeutic window". For drugs with small therapeutic windows the concentration in the blood stream must be kept within a relative narrow range to be effective without causing side effects or toxicity.
Baclofen does not have a small therapeutic window and the effective dose can vary dramatically from one individual to another for a variety of reasons. We therefore start with low doses and gradually increase the dose until a desired effect is observed or unacceptable side effects occur.
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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