I have had RRMS for 19 years. Now age 58 I only had treatment by choice with Copaxone for less than a year and developed pericardial effusions. Now my neurologist is considering Aubagio. My labs just came back. JCV AB is 1.16. I know PML does not usually occur on Aubagio but can PML occur by just having MS?
PML is an opportunistic infection meaning that the immune system has to be weakened to allow the opportunity for this rare infection of the nervous system. MS alone does not weaken the immune system, but some of our MS therapies can do so and have been linked to PML (i.e., Tysabri, Tecfidera, and Gilenya).
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist at Kaiser Permanente