Here is My Question:
Can Ocrevus and Dupixent be used together?
I can only find one case report of the concurrent use of an anti-CD20 monoclonal antibody (i.e., rituximab, ocrelizumab or ofatumumab) in a patient also on Dupixent, a monoclonal antibody targeting IL-4 and IL-13. We have anecdotally used anti-CD20 monoclonal antibody therapies in a few MS patients on Dupixent for eosinophilic syndromes and asthma. While we have not seen any adverse effects attributable to this combination therapy, we have not treated enough patients to confidently state that this combination of treatments is completely safe.
Physicians are trained to make treatment decisions when evidence is lacking. Your physicians will weigh the information available (risks and benefits) and advise you based on your circumstances.
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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