Here is My Question:
I have RRMS and I’m on Ocrevus. I have had a lot of problems lately with symptoms. I had my second full dose of Ocrevus a week ago. My recent blood work showed a generally normal CBC with a WBC at the low edge but my monocytes % was elevated but only 11. Would this possibly have anything to do with my recent Ocrevus infusion? MS in general? Or is it something I should get looked into for other causes? I looked my labs over the last few years and my monocytes % have steadily increased and have been between 9-11 for a few years. I know it’s mild so I was wondering if I should have any concern outside of MS.
Relative percentages of lymphocytes will change when using immunotherapy. The absolute numbers are more important. Mild elevations are not likely to be clinically meaningful. Keep in mind that symptomatic therapy is a different discussion than disease modifying therapy (ie, Ocrevus).
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist for Kaiser Permanente
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