Are my symptoms due to missing my dose?

Here is My Question:
Hi, I’m 38 and I have RRMS and have been on Ocrevus since last May. I have many symptoms and am on disability especially due to my cognitive problems. Things may have been less noticeable on Ocrevus but I have now missed my 2nd full dose and am have terrible trouble with memory, understanding, and “time” if that makes sense. I am also having a lot of physical issues like leg weakness and muscle spasms that I had before but not this bad. The cognitive issues are what’s getting me the most. Could it be related to delaying my Ocrevus? Should I consider just doing the infusion now and isolating more diligently? I have a terrible time getting through to my neuro which is so hard during this time. I’m just terrified that things will get worse if I delay much further. Maybe it doesn’t make much sense but is this possibly something related to the delay in the dose? I live in Louisiana but not in New Orleans. But regardless, the COVID is a big issue around here.

Answer:
Thanks for your question and including so many useful details. It sounds like you received your first cycle of Ocrevus in May 2019 (the two 300 mg doses are the first cycle) and cycle # 2 probably in November 2019. If this is correct you are still within 1 month of your 3rd cycle (your second full dose infusion). If my math is correct, I would be very surprised if your current symptoms are related to a reactivation of your disease. There are many other possibilities and I would encourage you to discuss this further with your MS Specialist.

Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego