I often get asked the question: “Should I participate in this clinical trial on …?” This is always a difficult question to answer because there are so many things to consider when making that decision. In order to know how to make a decision about whether or not to participate in a clinical trial, it is helpful to first understand what a clinical trial is and what the purpose is of a clinical trial.
Clinical trials are used to determine if a given intervention or medical device is safe and effective for a particular group of people. To this end, a clinical trial is carefully designed to answer a specific question, in a clearly defined group of people. For instance, a clinical trial may evaluate the safety and effectiveness of a certain exercise program (intervention) for people with MS who are still walking.
An intervention can include not only a behavioral treatment, such as exercise, but it can also involve the use of biological products (like stem cells), drugs (such as a given disease modifying drug), and devices (e.g., muscle stimulator).
Some clinical trials don’t involve an intervention, but are designed to evaluate the way that care is delivered, or the timing at which care is delivered. Sometimes, what is being studied is not yet being done in the clinic, or is being done for another patient population. For instance, electrical stimulation to muscles combined with cycling is being provided to people with spinal cord injury, but not routinely for people with MS. A clinical trial might then be designed to evaluate the safety and effectiveness of this intervention in people with MS.
One very important thing to remember is that a clinical trial is not clinical care. A clinical trial is a research study, to answer a question to which we do not yet know the answer. So, a clinical trial that is evaluating the health-related response to an intense exercise program in people with moderate to severe MS is not treatment. In fact, there are a number of outcomes that can come from this study:
Another important consideration is that a clinical trial generally involves a “control” group – a group that does not receive the intervention. When you enroll in a clinical trial, you will be randomly assigned to either the intervention group (as in you will receive the intervention), or the control group (you will not receive the intervention). Typically, this means that you will go through the same tests that those in the intervention group go through, but you will not receive treatment. You also may not be able to participate in other clinical trials or receive other treatments that might make it difficult to interpret the results of the trial.
Deciding whether or not to participate in a clinical trial depends on your situation, your needs, and your views. There are several positives to being in a clinical trial. When you are involved in a clinical trial you gain a better understanding of your condition, of the treatments available, and of the research process. All of these help you to be a more informed consumer, and allow you to have an active role in your care. You may get access to an intervention that is not yet available clinically, and you can do so while being monitored for safety. Also, what is learned from the trial may help other people like you in the future. For instance, if you have minimal disability due to your MS and you participate in a trial that shows that running will not cause a relapse or any negative effects, but will keep your healthier and more functional longer, this will tell people like you that they may also exercise to maintain greater health and function.
There are many clinical trials underway in MS. We are making much headway in terms of medical treatments, as well as rehabilitation and exercise. Being in a clinical trial will allow you to be a part of advancing MS care. Only you can make the decision about whether or not you should participate in a clinical trial. The first step is being an informed consumer. Stay tuned for the next blog where I will tell you about the different phases of a clinical trial in the United States.
In the meantime, here are some questions you can ask when making your decision about being in a clinical trial. Never be afraid to ask your questions – this is your right to know.
Ask the researcher:
Check with your insurance carrier:
Other resources (these are also listed on our "News and Events" page, so you can easily access these sites at any time from this website):
8/15/2014 05:10:15 am
Great article thank you
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About Dr. Debbie
Deborah Backus, PT, PhD is Director of Multiple Sclerosis Research at the Shepherd Center in Atlanta, Georgia. Dr. Debbie received her B.S. in Physical Therapy in 1986, and her Ph.D. in neuroscience in 2004.