Is there a PML risk with Aubagio treatment? After 3 years with Gilenya I came out JCV positive (1.73) after another year without treatment I am JCV 2.26 and my MS is active. Is it safe to try Aubagio?
I am not sure why you would stop Gilenya because of a positive JCV antibody test. There is no evidence that this test is useful for helping to reduce the risk of PML in patients on Gilenya. The reason is that the risk of PML is so small on Gilenya and all other DMTs except Tysabri.
So you could consider a large number of disease modifying therapies other than Tysabri.
Revere (Rip) Kinkel MD
Director of the Multiple Sclerosis Program
Director of Hillcrest Neurology
Professor of Clinical Neurosciences
University of California San Diego