A. Very good question and hard to give an answer that is true in all circumstances. Generally, steroids start working within the first week if not the first few days. A person still worsening 10 days after starting steroids is probably not responding, even though we usually use the two week cutoff to define a non-responder. In the example given it is more likely that the improvement was spontaneous. After all, we do call this phase of the disease relapsing remitting for a reason.