Here is my question:
I have severe asthma and my question is, will this medication (Nucala) interact with my betaseron? Has any other patient tried this combination? If so, side effects? Any studies?
Dupixent (dupilumab) and Nucala (mepolizumab) are monoclonal antibodies blocking the interaction of IL-4/IL-13 and IL-5, respectively, with their receptors. Both are used to treat Th2 mediated inflammatory diseases including atopic dermatitis, asthma and other hyper eosinophilic syndromes. There is, as yet no contraindication for either treatment in people with MS. To oversimplify an issue, there are theoretical concerns that inhibiting overactive Th2 responses with either treatment may activate MS. To date there is only one case report from the University of Rochester suggesting this possibility. That is all the information available currently.
Both Dupixent and Nucala are contraindicated in people with parasitic infections and some people with MS treat themselves with parasites (Helminths) to try and treat their disease. It would not be a good idea for these people on parasitic treatment with Helminths to take either Dupixent or Nucala.
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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