Here is My Question:
Why do I have to be off Tysabri for at least 8 weeks before beginning Ocrevus?
You do not have to be off of Tysabri for 8 weeks before you start Ocrevus or any other anti-CD20 monoclonal antibody therapy.
You only need documentation that there is no evidence of symptomatic or pre-symptomatic PML before you start Ocrevus. Usually an MRI scan of the brain is sufficient to document an absence of early PML. Once this is done you can start Ocrevus. If there is any question or doubt after an MRI is done, we usually do a lumbar puncture to sample CSF to make sure there is no evidence of PML before you start ocrevus. In most cases we are able to complete this evaluation and start Ocrevus in less than 2 months. In no case should you start ocrevus until a repeat MRI scan has been done to exclude early PML.
Revere P (Rip) Kinkel, MDProfessor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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