I'm currently on Tecfidera and am JC positive with a level of 1 : 20. My neurologist wants to start ritixumab in the next 3 weeks to cover basis for MS or neuromylitis. I'm terrified and scared of PML risks? Can you tell me risks based on level with ritixumab?
The risk of PML in people on Rituximab is less than 1 in 25,000.
There is no evidence that the JCV antibody index level affects the risk of PML in people on Rituximab
Therefore, your risk is extremely low unless your absolute lymphocyte count was lowered on Tecfidera (less than 700) and does not return to normal range before you start Rituximab.
Revere (Rip) Kinkel MD
Professor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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