Q: Is it possible that the same person could respond to prednisone, but not to methylprednisolone during a relapse? Aren't they too similar for this to be true?
A: Prednisone is usually given orally after a series of methylprednisolone infusions. It often appears that the prednisone works better if the benefits from the combined steroid treatments do not kick in while you are receiving the methylprednisolone infusions. In addition some patients experience side effects on the higher doses used with methylprednisolone and these side effects may counter any apparent benefit.
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