Here is My Question:
I have a paralyzed right diaphragm with resulting atelectasis of the right lower lobe and part of middle lobe. My last MRI in 8/18 didn't show any disease C3-5. I have been off Aubagio since 7/18 due to side effects (abnormal low WBC) and will be restarting it this month. Will be repeating MRI to assess for new disease. How often does MS cause phrenic nerve damage?
Unilateral paralysis of a diaphragm is relatively rare in MS, although studies performed years ago suggested subclinical involvement of diaphragm function in a larger number of patients. This paralysis does not require involvement of the cord segments with the anterior horn cells supplying innervation to the diaphragm through the phrenic nerve (C3,4 and 5). This can also be the result of involvement of central motor pathways above this level in the brainstem.
Revere (Rip) Kinkel MD
Professor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego
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