What is your opinion on RRMS treatment that includes minocycline? The studies by Dr. Ian Duncan and others look very promising.
There is evidence that minocycline may beneficially modulate immune responses and decrease microglial activation in various animal models. The effect on microglial activation is thought to be potentially neuroprotective although there is also evidence that minocycline may inhibit remyelination which would not be so good.
Studies in MS are mixed. I seem to recall an older combination study with interferons that showed minimal benefit and resulted in an increased incidence in vaginal infections. I don’t think this study was ever published since I can not find it on Pubmed. There was a small Canadian study of minocyline in combination with glatiramer acetate (Copaxone) in MS patients that suggested some potential benefit in MS but the number of patients studied was very small and the authors rightfully warned about the need for further clinical trials before using minocyline in clinical practice, especially when so many good therapies are already available.
Revere (Rip) Kinkel MD
Director of the Multiple Sclerosis Program
Professor of Clinical Neurosciences
University of California San Diego