One of my twin daughters was diagnosed with MS in late 2013 at age 11. She was first on Avonex (from 11/2013 – 8/2014) and then changed to Copaxone from 9/2014 to present. The doctor said she had developed antibodies to Avonex. What does that mean?
Some patients have an immune response to medications, like interferon and can develop antibodies to the drug. These antibodies are the same proteins that we develop against infections to prevent us from getting sick, but in the setting of interferon a minority of patients develop antibodies to the drug. In that situation, the drug can become less effective.
Benjamin M. Greenberg, MD, MHS
Director, Transverse Myelitis and Neuromyelitis Optica Program
Director, Pediatric Demyelinating Disease Program
Department of Neurology and Neurotherapeutics
Department of Pediatrics
Cain-Denius Scholar of Mobility Disorders
University of Texas Southwestern Medical Center