Answer: Susceptibility to relapses after stopping Tysabri is somewhat unpredictable. In general, people with active disease in the year prior to starting Tysabri are much more prone to these Tysabri withdrawal relapses. Active disease would include:
1. At least 1 enhancing or new T2 lesion on more than 1 MRI scan in the prior year or more than 1 enhancing or new T2 lesion on an MRI prior to starting tysabri while still receiving another therapy
2. One moderate to severe relapse or more than one mild relapse in the year prior to starting tysabri
Unfortunately this criteria does not predict even the majority of people with relapses after stopping Tysabri
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