I was diagnosed with MS three years ago and have been on Tysabri for 2 1/2. My main issue is fatigue - so much so that I am unable to work a full time job...I have been on ProVigil, NuVigil and am currently taking Adderall XR 20 mg 2x a day & Adderall IR 10mg 2x a day...even with proper sleep, diet and exercise, I am exhausted - all of the time. If someone want to go out at 8pm (I am a single 36-year-old with no children), I have to change the time. What can I do?
Start by reading the blog I wrote about MS fatigue on the website last year (link attached). Probably the main reason stimulant drugs do not work in many MS patients is that they are trying to treat the wrong thing. It’s similar to picking the wrong antibiotic to treat an infection. Follow the steps outlined in this blog and come back to us with a more detailed description of your fatigue experience. By the way, if you feel excessively sleepy during the day, we do not call this fatigue; we call this excessive daytime sleepiness.
Revere (Rip) Kinkel MD
Director of the Multiple Sclerosis Program
Director of Hillcrest Neurology
Professor of Clinical Neurosciences
University of California San Diego