I've been taking Tecfidera for 2 1/2 years. Recently, I did a series of MRI's to compare with the baseline MRI's I did before starting the drug. I have one new lesion. Does this mean that Tecfidera does not work for me? Or would I have more new lesions if I did not take the drug? My neurologist does not know the answer to this question.
Generally speaking, 1 new lesion over 2.5 years is considered acceptable. Keep in mind that Tecfidera, as with all of the therapies, are partially effective, and we expect some disease activity.
More than MRI response is used to determine the success of Tecfidera. I would suggest that if you are doing well functionally, and you have reasonable lab work (i.e., white blood cell levels), that it is likely advisable to continue on the medication.
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist at Kaiser Permanente