Is fatigue related foot drop more, less or similarly associated with MS compared to peroneal compression foot drop? Not much available on google on this topic. Many thanks.
Foot drop due to MS is due to demyelinating disease of the central nervous system (brain and spinal cord). Compressive peroneal neuropathy results in footdrop but is an injury of the peripheral nervous system (which MS does not effect). Either injury (central or peripheral) can transiently worsen with exertion (i.e., leading to fatiguable weakness).
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist at Kaiser Permanente