For how long is it recommend to take taking 325mg aspirin with Tecfidera? Is there another alternative?
An adult aspirin (325mg) is typically used to pre-treat the flushing symptoms associated with Tecfidera. There is not a standard guideline regarding the duration of pre-treatment, but it should be noted that flushing as it relates to Tecfidera tends to improve or resolve within the first month of initiating the medication. If you've been on Tecfidera and are not experiencing the flushing reaction, consider stopping the aspirin as it may no longer be needed. Since aspirin can help treat other serious conditions, you should first consult with your doctor.
Another option is to take Tecfidera after a high protein and fat meal (think peanut butter) as this may also limit the flushing side effect.
There is no evidence that an aspirin will help the other common side effect of Tecfidera: stomach and GI tract upset. However, taking the Tecfidera after a meal may help mitigate this temporary side effect as well.
A. Scott Nielsen MD MMSc
Virginia Mason Multiple Sclerosis Center