I'm going to be starting Rituximab Infusion soon. I have Relapsing MS. Can you explain how this infusion works?
Rituximab is a chimeric monoclonal antibody engineered to bind to and kill any cell in your circulation that has a protein on it’s surface called CD20. CD20 is primarily expressed on the surface of B cells, a subtype of lymphocyte, making this a very selective therapy that leaves the rest of your immune system unaffected.
The B cells destroyed by rituximab are thought to be heavily involved in both the development and persistence of the inflammation associated with Multiple Sclerosis. This is the likely reason that Rituximab is so effective in relapsing forms of MS, a stage of the disease where injury to the nervous system is primarily caused by new and persistent inflammation.
Revere (Rip) Kinkel MD
Professor of Clinical Neurosciences
Director of the Multiple Sclerosis Program
Clinical Neurosciences Director
University of California San Diego