Here is My Question:
While on Tysabri, I asked my neurologist if I could donate blood and he advised against it. I'm now on Tecfidera, so can I donate blood now?
Your neurologist is correct; Tysabri is a monoclonal antibody that binds to a receptor on white blood cells; there is a good chance that some of the bound Tysabri would be transferred as part of the blood donation, although it is doubtful that this would be harmful.
Tecfidera is rapidly metabolized to monomethyl fumarate and will be completely gone by the time the blood donation is prepared. I do not think there will be any problem donating blood on this treatment but the blood donation site may have separate rules. Check with them first; remember, it wasn’t long ago that MS patients were totally prohibited from donating blood. The red cross took MS off the list of exclusionary diagnoses 5 to 10 years ago, but some donation centers may still prohibit MS patients from donating blood. Good question.