Can these test proven MS? Four OCBs with no serum bands, low igg syn rate and index, mild elevation of myelin basic protein and low total protein. CSF ans serum high elevations of igg. My MRI's 2 years ago show small low density lesion on basal ganglia(possibly existing ischemia, per radiologist). Recent MRI - tiny focus subtle diffusion restriction in the left parasagittal ventral pon belly, possibly reflecting a subacute basilar perforator small vessel infarct. also scattered foci of t2 prolongation involving periventricular and subcortical white matter of the bilateral cerebral hemispheres in the setting of borderline volume loss.with some minor motor with dominate severe sensory and autonomic dysfunction.
The diagnosis of MS is mostly based on clinical history. The use of MRI findings and OCBs in the spinal fluid can be of assistance but the final clinical diagnosis depends mostly on the history and neurologic exam. That being said, + OCBs require 5 OCBs in the CSF that are not present in the serum.
Benjamin Osborne, MD
Associate Professor of Neurology and Ophthalmology
Director, Neuromyelitis Optica (NMO) Clinic
Director, Neuro-Ophthalmology Clinic
Associate Director of the NIH/Georgetown Neurology Residency Program
Medstar Georgetown University Hospital
3800 Reservoir Road, NW 7PHC
Washington, DC 20007