Can a MRI scan show a damage to the nerve fiber, which causes permanent disability?
MRI can show tissue loss (ie, transacted axons and whole brain atrophy) which is associated with permanent disability. When MRI scans are reviewed, it is easy to focus on the white lesions (called T2 or FLAIR lesions). However T1 'black holes' reflect tissue loss. The disease modifying therapies have some ability to reduce the likelihood of T2 lesions from progressing into T1 black holes.
A. Scott Nielsen MD MMSc
Neurologist and MS Specialist at Kaiser Permanente